{"product_id":"acvr1-polyclonal-antibody-bt-ap06041","title":"ACVR1 Polyclonal Antibody - BT-AP06041","description":"\u003cp\u003eACVR1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06041-20, BT-AP06041-50, BT-AP06041-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins| composed of a ligand-binding extracellular domain with cysteine-rich region| a transmembrane domain| and a cytoplasmic domain with predicted serine\/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding| resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Developmental biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ACVR1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Activin receptor type-1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q04771; Mouse: P37172; Rat: P80201\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Activin receptor type-1;EC 2.7.11.30;Activin receptor type I;ACTR-I;Activin receptor-like kinase 2;ALK-2;Serine\/threonine-protein kinase receptor R1;SKR1;TGF-B superfamily receptor type\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 90\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239042146483,"sku":"BT-AP06041-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239042179251,"sku":"BT-AP06041-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239042212019,"sku":"BT-AP06041-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_05ad9445-95cf-4936-9b18-452ef21574a1.png?v=1769388310","url":"https:\/\/afsbio.com\/products\/acvr1-polyclonal-antibody-bt-ap06041","provider":"AFSBio Inc.","version":"1.0","type":"link"}