{"product_id":"acy1-polyclonal-antibody-bt-ap14120","title":"ACY1 Polyclonal Antibody - BT-AP14120","description":"\u003cp\u003eACY1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14120-20, BT-AP14120-50, BT-AP14120-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a cytosolic| homodimeric| zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group| and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1| a region reduced to homozygosity in small-cell lung cancer (SCLC)| and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart| and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency| a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription als\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Metabolism; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ACY1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Aminoacylase-1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q03154; Mouse: Q99JW2\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Aminoacylase-1;ACY-1;EC 3.5.1.14;N-acyl-L-amino-acid amidohydrolase\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 95\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239042310323,"sku":"BT-AP14120-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239042343091,"sku":"BT-AP14120-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239042375859,"sku":"BT-AP14120-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c8b94ebf-bd6b-4658-9d51-78a08ea849c3.png?v=1769388313","url":"https:\/\/afsbio.com\/products\/acy1-polyclonal-antibody-bt-ap14120","provider":"AFSBio Inc.","version":"1.0","type":"link"}