{"product_id":"ada-rabbit-polyclonal-antibody-es9364","title":"ADA Rabbit Polyclonal Antibody - ES9364","description":"\u003cp\u003eADA Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES9364-50, ES9364-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein. at AA range: 80-160\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: ADA\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ADA Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412), Expressed at the time of weaning in gastrointestinal tissues,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 39kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Purine metabolism, Metabolic pathways, Nucleotide metabolism, Primary immunodeficiency\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: Adenosine + H(2)O = inosine + NH(3)\u003cbr\u003e\nDisease: Defects in ADA are the cause of severe combined immunodeficiency autosomal recessive T-cell-negative\/B-cell-negative\/NK-cell-negative due to adenosine deaminase deficiency (ADASCID) [MIM: 102700]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. ADA-SCID is an autosomal recessive form accounting for about 50% of non-X-linked SCIDs. ADA deficiency has been diagnosed in chronically ill teenagers and adults (late or adult onset). Popul\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane, Peripheral membrane protein, Extracellular side Cell junction Cytoplasmic vesicle lumen Cytoplasm Lysosome Colocalized with DPP4 at the cell surface\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: ADA ADA1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P03958\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q920P6\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314127524019,"sku":"ES9364-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314127556787,"sku":"ES9364-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/ada-rabbit-polyclonal-antibody-es9364","provider":"AFSBio Inc.","version":"1.0","type":"link"}