{"product_id":"adam10-polyclonal-antibody-bz16999","title":"ADAM10 Polyclonal Antibody-BZ16999","description":"\u003cp\u003eADAM10 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BZ16999-50, BZ16999-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O14672\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB, IP\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000 IP: 1\/20\u003c\/p\u003e \n\n\u003cp\u003eBackground: The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 84 kDa; Observed MW: 90,68 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of ADAM10 in NTERA-2 lysates using ADAM10 antibody.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CDw156; CD156c; ADAM10; KUZ; MADM\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human ADAM10\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42916161978547,"sku":"BZ16999-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42916162011315,"sku":"BZ16999-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_f6352de0-1062-480f-b59f-b31ec71f75e0.jpg?v=1703418178","url":"https:\/\/afsbio.com\/products\/adam10-polyclonal-antibody-bz16999","provider":"AFSBio Inc.","version":"1.0","type":"link"}