{"product_id":"adamts2-polyclonal-antibody-bs60092","title":"ADAMTS2 Polyclonal Antibody-BS60092","description":"\u003cp\u003eADAMTS2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS60092-50, BS60092-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: A disintegrin and metalloproteinase with thrombospondin motifs 2; ADAM-TS 2; ADAM-TS2; ADAMTS-2; Procollagen I N-proteinase; PC I-NP; Procollagen I\/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI; PCINP; PCPNI\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O95450\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. ADAMTS-2 cleaves the propeptides of Collagen Type I and II, but not Collagen Type III, prior to fibril assembly. It may also play a role in development aside from collagen biosynthesis. ADAMTS-2 is secreted and associated with the extracellular matrix, with the highest levels in skin, bone, tendon and aorta. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type VIIC (EDS VIIC), a recessively inherited connective-tissue disorder characterized clinically by severe skin fragility and joint hypermobility.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ADAMTS2 polyclonal antibody detects endogenous levels of ADAMTS2 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 135 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of ADAMTS2 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: MCF-7 whole cell lysate\u003cbr\u003e\nLane 2: sp2\/0 whole cell lysate\u003cbr\u003e\nLane 3: H9C2 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide corresponding to residues in Human ADAMTS2.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42911828443315,"sku":"BS60092-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42911828476083,"sku":"BS60092-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_83ec4020-f2d5-4aea-873f-68a362e7a080.jpg?v=1703180241","url":"https:\/\/afsbio.com\/products\/adamts2-polyclonal-antibody-bs60092","provider":"AFSBio Inc.","version":"1.0","type":"link"}