{"product_id":"adck3-n323-polyclonal-antibody-bs2099","title":"ADCK3 (N323) Polyclonal Antibody-BS2099","description":"\u003cp\u003eADCK3 (N323) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2099-50, BS2099-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q8NI60\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: CABC1 (chaperone activity of bc1 complex-like), also known as COQ8 or ADCK3 (aarF domain-containing protein kinase 3) is a 647 amino acid mitochondrial protein that belongs to the protein kinase superfamily. Ubiquitously expressed with higher expression in heart and skeletal muscle, CABC1 is thought to function as a chaperone in the proper assembly of protein complexes found in the respiratory chain. CABC1 expression is induced both in response to DNA damage and by the tumor suppressor p53. When CABC1 expression is inhibited, p53-induced apoptosis is partially suppressed, suggesting a possible role for CABC1 in tumor suppression. Mutations in the gene encoding CABC1 may\u003cbr\u003e\nbe implicated in ubiquinone deficiency, which can lead to cerebellar ataxia and seizures. Four isoforms of CABC1 exist due to alternative splicing events.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ADCK3 (N323) polyclonal antibody detects endogenous levels of ADCK3 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of ADCK3 (N323) polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane1:CT26 whole cell lysate(40ug)\u003cbr\u003e\nLane2:H9C2 whole cell lysate(40ug)\u003cbr\u003e\nLane3:EC9706 whole cell lysate(40ug)\u003cbr\u003e\nLane4:A2780 whole cell lysate(40ug)\u003cbr\u003e\nLane5:Panc1 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 72 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Atypical kinase COQ8A, mitochondrial; Chaperone activity of bc1 complex-like; Chaperone-ABC1-like; Coenzyme Q protein 8A; aarF domain-containing protein kinase 3; COQ8A; ADCK3; CABC1; PP265\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 293-353 of Human ADCK3.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910478500019,"sku":"BS2099-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910478532787,"sku":"BS2099-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_c82687b6-97dc-453c-b69f-2eb42dcbfe2e.jpg?v=1703093237","url":"https:\/\/afsbio.com\/products\/adck3-n323-polyclonal-antibody-bs2099","provider":"AFSBio Inc.","version":"1.0","type":"link"}