{"product_id":"adcy-1-d252-polyclonal-antibody-bs2391","title":"ADCY 1 (D252) Polyclonal Antibody-BS2391","description":"\u003cp\u003eADCY 1 (D252) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2391-50, BS2391-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q08828\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to Gα s) for GTP, the dissociation of GTP-Gα s from Gβγ and Gα s)-mediated activation of adenylyl cyclase. Adenylyl cyclases type I (AC I) and III (AC III) have distinct staining within the cell nucleus of rat brain sensory neurons. A cyclase I, also known as AC1 or ADCY1, is a 1,119 amino acid multi-pass membrane protein expressed in the brain, retina and adrenal medulla. A cyclase I binds two magnesium ions per subunit and may be involved in regulatory processes in the central nervous system.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ADCY 1 (D252) polyclonal antibody detects endogenous levels of Adenylate cyclase type 1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 130 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of ADCY 1 (D252) Antibody at 1:500 dilution\u003cbr\u003e\n Lane 1: HEK293T whole cell lysate (40ug)\u003cbr\u003e\n Lane 2: MCF-7 whole cell lysate (40ug)\u003cbr\u003e\n Lane 3: C6 whole cell lysate (40ug)\u003cbr\u003e\n Lane 4: AML-12 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of ADCY 1 (D252) pAb in paraffin-embedded human breast carcinoma tissue at 1:50, showing cytoplasm and membrane staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase., Immunohistochemistry (IHC) analyzes of ADCY 1 (D252) pAb in paraffin-embedded human rectum carcinoma tissue at 1:50, showing cytoplasm and membrane staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Adenylate cyclase type 1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)\/calmodulin-activated adenylyl cyclase; ADCY1; A Cyclase I\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 230-280 of Human ADCY 1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42993795203251,"sku":"BS2391-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42993795236019,"sku":"BS2391-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_f6f8faa0-db17-4da1-b283-61ea7396737a.jpg?v=1706183644","url":"https:\/\/afsbio.com\/products\/adcy-1-d252-polyclonal-antibody-bs2391","provider":"AFSBio Inc.","version":"1.0","type":"link"}