{"product_id":"af-4-polyclonal-antibody-ra21702","title":"AF-4 Polyclonal Antibody - RA21702","description":"\u003cp\u003eAF-4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA21702-50, RA21702-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: AF4\/FMR2 family member 1 (AFF1) Homo sapiens This gene encodes a member of the AF4\/ lymphoid nuclear protein related to AF4\/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4\/ lymphoid nuclear protein related to AF4\/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:500-2000 Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: AFF1; AF4; FEL; MLLT2; PBM1; AF4\/FMR2 family member 1; ALL1-fused gene from chromosome 4 protein; Protein AF-4; Protein FEL; Proto-oncogene AF4\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p; IF (paraffin section) ; WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 4299\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 130\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P51825\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121077903539,"sku":"RA21702-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121077936307,"sku":"RA21702-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_168f72ea-eeee-4e6c-8622-740b68681272.png?v=1773370610","url":"https:\/\/afsbio.com\/products\/af-4-polyclonal-antibody-ra21702","provider":"AFSBio Inc.","version":"1.0","type":"link"}