{"product_id":"af-le-purified-anti-mouse-cd279-pd-1-antibody-29f-1a12-e-ab-f11310","title":"AF\/LE Purified Anti-Mouse CD279\/PD-1 Antibody [29F.1A12] - E-AB-F11310","description":"\u003cp\u003eAF\/LE Purified Anti-Mouse CD279\/PD-1 Antibody [29F.1A12]\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500μg, 1mg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-F11310-500, E-AB-F11310-1\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD279\/PD-1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PD-1, Programmed Death-1,\u003c\/p\u003e \n\n\u003cp\u003eConjugation: None (Purified antibody-Azide Free\/Low endotoxin)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rat\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: FCM,Block,Neut\u003c\/p\u003e\n\n\u003cp\u003eUsage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Rat IgG2a, κ\u003c\/p\u003e\n\n\u003cp\u003eClone No.: 29F.1A12\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q02242\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.5 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eControl Catalogue Number: E-AB-F098330\u003c\/p\u003e\n\n\u003cp\u003eBuffer: 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)\/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is \u0026lt; 2 EU\/mg as Determined by LAL gel clotting assay.\u003c\/p\u003e\n\n\u003cp\u003eGene ID: 18566\u003c\/p\u003e\n\n\u003cp\u003eStorage: This product can be stored at 2-8°C for 12 months. Do not freeze.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"500μg","offer_id":43157123694771,"sku":"E-AB-F11310-500","price":553.0,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":43157123727539,"sku":"E-AB-F11310-1","price":833.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_90bfd0e3-61fd-4507-ade8-6b2e542811e3.png?v=1710511449","url":"https:\/\/afsbio.com\/products\/af-le-purified-anti-mouse-cd279-pd-1-antibody-29f-1a12-e-ab-f11310","provider":"AFSBio Inc.","version":"1.0","type":"link"}