{"product_id":"af-le-purified-anti-mouse-cd54-antibody-yn1-1-7-4-e-ab-f10180","title":"AF\/LE Purified Anti-Mouse CD54 Antibody [YN1\/1.7.4] - E-AB-F10180","description":"\u003cp\u003eAF\/LE Purified Anti-Mouse CD54 Antibody [YN1\/1.7.4]\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500μg, 1mg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-F10180-500, E-AB-F10180-1\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD54\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Intercellular adhesion molecule 1, Icam1, MALA-2, MyD10, CD54, Icam-1,\u003c\/p\u003e \n\n\u003cp\u003eConjugation: None (Purified antibody-Azide Free\/Low endotoxin)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rat\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: FCM\u003c\/p\u003e\n\n\u003cp\u003eUsage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Rat IgG2b, κ\u003c\/p\u003e\n\n\u003cp\u003eClone No.: YN1\/1.7.4\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P13597\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes\/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a\/CD18) and Mac-1 (CD11b\/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1\/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.5 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eControl Catalogue Number: E-AB-F098430\u003c\/p\u003e\n\n\u003cp\u003eBuffer: 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)\/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is \u0026lt; 2 EU\/mg as Determined by LAL gel clotting assay.\u003c\/p\u003e\n\n\u003cp\u003eGene ID: 15894\u003c\/p\u003e\n\n\u003cp\u003eStorage: This product can be stored at 2-8°C for 12 months. Do not freeze.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"500μg","offer_id":43157079589043,"sku":"E-AB-F10180-500","price":343.0,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":43157079621811,"sku":"E-AB-F10180-1","price":623.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_df8f3d40-d95f-4562-b6de-bf1ab4e20a14.png?v=1710510490","url":"https:\/\/afsbio.com\/products\/af-le-purified-anti-mouse-cd54-antibody-yn1-1-7-4-e-ab-f10180","provider":"AFSBio Inc.","version":"1.0","type":"link"}