{"product_id":"affinity-gel-conjugated-pan-succinyl-lysine-rabbit-mab-a26021","title":"Affinity Gel-conjugated Pan Succinyl-Lysine Rabbit mAb - A26021","description":"\u003cp\u003eAffinity Gel-conjugated Pan Succinyl-Lysine Rabbit mAb\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: A26021-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The lysine residue in proteins can undergo to many types of PTMs, such as methylation, acetylation, biotinylation, ubiquitination, ubiquitin-like modifications, propionylation and butyrylation, then leading to the remarkable complexity of PTM networks. Succinylation is a posttranslational modification (PTM) where a succinyl group is added to a Lys (K) residue of a protein molecule .it has been shown that the lysine succinylation responses to different physiological conditions and is evolutional conserved. It has been identified 2, 565 succinylation sites from 779 proteins and revealed that lysine succinylation have potential impacts on enzymes involved in mitochondrial metabolism including the amino acid degradation, tricarboxylic acid (TCA) cycle and fatty acid metabolism Thelysine succinylation also occurs in histones, suggesting that it may play an important role in regulating chromatin structures and functions as well\u003c\/p\u003e\n\n\u003cp\u003eCategory: Other Modified Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: IP-MS\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Species independent\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS with 50% glycerol, 0.09% Sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: IP-MS, 40 μL antibody (bead slurry) for 200μg-400μg extracts of whole cell\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Protein Post-translational Modification, PTM.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: Pan-Succinyl-K\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC55837-AG\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"Default Title","offer_id":45190101205171,"sku":"A26021-100","price":651.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_3c514b56-6080-4449-be14-e4ad05d40d9c.png?v=1766442478","url":"https:\/\/afsbio.com\/products\/affinity-gel-conjugated-pan-succinyl-lysine-rabbit-mab-a26021","provider":"AFSBio Inc.","version":"1.0","type":"link"}