{"product_id":"ak1d1-rabbit-polyclonal-antibody-es18425","title":"AK1D1 Rabbit Polyclonal Antibody - ES18425","description":"\u003cp\u003eAK1D1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES18425-50, ES18425-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human AK1D1 AA range: 258-308\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: AK1D1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of AK1D1 at Human\/Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Highly expressed in liver, Expressed in testis and weakly in colon,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 36kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Primary bile acid biosynthesis, Steroid hormone biosynthesis, Metabolic pathways\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone\u003cbr\u003e\nCatalytic Activity: 5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH\u003cbr\u003e\nDisease: Defects in AKR1D1 are the cause of congenital bile acid synthesis defect type 2 (CBAS2) [MIM: 235555], also known as cholestasis with delta(4)-3-oxosteroid 5-beta-reductase deficiency. Patients with this liver disease show absence or low levels of chenodeoxycholic acid and cholic acid in plasma and urine\u003cbr\u003e\nEnzyme Regulation: Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM\u003cbr\u003e\nFunction: Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as subs\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: AKR1D1 SRD5B1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: AK1D1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 208665\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8VCX1\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 192242\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P31210\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315836604595,"sku":"ES18425-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315836637363,"sku":"ES18425-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/ak1d1-rabbit-polyclonal-antibody-es18425","provider":"AFSBio Inc.","version":"1.0","type":"link"}