{"product_id":"akap-250-polyclonal-antibody-bt-ap00325","title":"AKAP 250 Polyclonal Antibody - BT-AP00325","description":"\u003cp\u003eAKAP 250 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00325-20, BT-AP00325-50, BT-AP00325-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP12 (A-kinase anchoring protein 12) encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: AKAP12\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: AKAP 250 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 191483\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q02952; Mouse: Q9WTQ5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: AKAP12; AKAP250; A-kinase anchor protein 12; AKAP-12; A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 9590\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240100454579,"sku":"BT-AP00325-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240100487347,"sku":"BT-AP00325-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240100520115,"sku":"BT-AP00325-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_9b25823a-2fcc-4945-bdd6-ecd724343b0f.png?v=1769403405","url":"https:\/\/afsbio.com\/products\/akap-250-polyclonal-antibody-bt-ap00325","provider":"AFSBio Inc.","version":"1.0","type":"link"}