{"product_id":"akt-pan-phospho-ser473-rabbit-monoclonal-antibody-ra12277","title":"Akt (pan) (Phospho Ser473) Rabbit Monoclonal Antibody - RA12277","description":"\u003cp\u003eAkt (pan) (Phospho Ser473) Rabbit Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA12277-50, RA12277-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: AKT1 gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine\/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K) . AKT\/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells.\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 207;208;10000\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 60\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P31749;P31751;Q9Y243\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119063654579,"sku":"RA12277-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119063687347,"sku":"RA12277-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d3a4bf70-14d6-4258-9b15-153c55a103a4.png?v=1773344697","url":"https:\/\/afsbio.com\/products\/akt-pan-phospho-ser473-rabbit-monoclonal-antibody-ra12277","provider":"AFSBio Inc.","version":"1.0","type":"link"}