{"product_id":"akt2-monoclonal-antibody-bt-mca4701","title":"AKT2 Monoclonal Antibody - BT-MCA4701","description":"\u003cp\u003eAKT2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4701-50, BT-MCA4701-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53kDa), belongs to the AKT serine\/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK\/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction, Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: AKT2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, ICC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 1B6\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: AKT2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human AKT2 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 60kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P31751\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PKBB, PRKBB, PKBBETA, RAC-BETA\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 208\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238622716083,"sku":"BT-MCA4701-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238622748851,"sku":"BT-MCA4701-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_71fe8607-3586-4df0-a547-6a194501d4bd.png?v=1769383163","url":"https:\/\/afsbio.com\/products\/akt2-monoclonal-antibody-bt-mca4701","provider":"AFSBio Inc.","version":"1.0","type":"link"}