{"product_id":"alk-phospho-tyr1078-rabbit-polyclonal-antibody-bt-ap01622","title":"ALK (Phospho-Tyr1078) Rabbit Polyclonal Antibody - BT-AP01622","description":"\u003cp\u003eALK (Phospho-Tyr1078) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01622-20, BT-AP01622-50, BT-AP01622-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a receptor tyrosine kinase| which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain| an hydrophobic stretch corresponding to a single pass transmembrane region| and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged| mutated| or amplified in a series of tumours including anaplastic large cell lymphomas| neuroblastoma| and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene| which result in creation of multiple fusion genes in tumourigenesis| including ALK (chromosome 2)\/EML4 (chromosome 2)| ALK\/RANBP2 (chromosome 2)| ALK\/ATIC (chromosome 2)| ALK\/TFG (chromosome 3)| ALK\/NPM1 (chromosome 5)| ALK\/SQSTM1 (chromosome\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Neuroscience; Tags and cell markers\u003c\/p\u003e \n\n\u003cp\u003eTarget Protein: ALK\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Alkbh8\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9UM73; Mouse: P97793\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ALK;Tyr1078; ALK tyrosine kinase receptor; EC 2.7.10.1; Anaplastic lymphoma kinase; CD antigen CD246\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 238; Mouse: 11682\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238963110067,"sku":"BT-AP01622-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238963142835,"sku":"BT-AP01622-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238963175603,"sku":"BT-AP01622-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_9e82e902-f7c7-4705-a0c9-c2baccaf43eb.png?v=1769387319","url":"https:\/\/afsbio.com\/products\/alk-phospho-tyr1078-rabbit-polyclonal-antibody-bt-ap01622","provider":"AFSBio Inc.","version":"1.0","type":"link"}