{"product_id":"alk-rabbit-pab-a27758","title":"ALK Rabbit pAb - A27758","description":"\u003cp\u003eALK Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A27758-20, A27758-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2) \/EML4 (chromosome 2), ALK\/RANBP2 (chromosome 2), ALK\/ATIC (chromosome 2), ALK\/TFG (chromosome 3), ALK\/NPM1 (chromosome 5), ALK\/SQSTM1 (chromosome 5), ALK\/KIF5B (chromosome 10), ALK\/CLTC (chromosome 17), ALK\/TPM4 (chromosome 19), and ALK\/MSN (chromosome X) .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 176kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 80kDa\/140kDa\/220kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment) .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 238\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9UM73\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ALK1; CD246; NBLST3\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:1500 - 1:3000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Protein phosphorylation, Cancer, Signal Transduction, Kinase, Tyrosine kinases, Cell Biology Developmental Biology, Growth factors, Immunology Inflammation, CDs, Neuroscience, Cell Type Marker, Neuron marker.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: ALK\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189887295667,"sku":"A27758-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189887328435,"sku":"A27758-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_5c808f41-ac79-4bec-b3e1-ddf231db257d.png?v=1766437494","url":"https:\/\/afsbio.com\/products\/alk-rabbit-pab-a27758","provider":"AFSBio Inc.","version":"1.0","type":"link"}