{"product_id":"alkaline-phosphatase-alpl-polyclonal-antibody-e-ab-93077","title":"Alkaline Phosphatase (ALPL) Polyclonal Antibody - E-AB-93077","description":"\u003cp\u003eAlkaline Phosphatase (ALPL) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-93077-60, E-AB-93077-120, E-AB-93077-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Alkaline Phosphatase (ALPL)\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ALPL; AP-TNAP; APTNAP; HOPS; TNAP\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P05186\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver\/bone\/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human Alkaline Phosphatase\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 48kDa\/51kDa\/57kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 80KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146674634931,"sku":"E-AB-93077-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146674667699,"sku":"E-AB-93077-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146674700467,"sku":"E-AB-93077-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_618844d9-55a0-478f-b083-97cd76081469.png?v=1710299880","url":"https:\/\/afsbio.com\/products\/alkaline-phosphatase-alpl-polyclonal-antibody-e-ab-93077","provider":"AFSBio Inc.","version":"1.0","type":"link"}