{"product_id":"alkbh1-polyclonal-antibody-bs7984","title":"ALKBH1 Polyclonal Antibody-BS7984","description":"\u003cp\u003eALKBH1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7984-50, BS7984-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q13686\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB IP\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB\t1:500 - 1:2000\u003cbr\u003e\nIP\t1:50 - 1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ALKBH1 polyclonal antibody detects endogenous levels of ALKBH1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 43 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot (WB) analysis of ALKBH1 polyclonal antibody\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: ABH; \u003cbr\u003e\nABH1; \u003cbr\u003e\nalkB; \u003cbr\u003e\nAlkB, alkylation repair homolog 1 (E. coli); \u003cbr\u003e\nALKB1_HUMAN; \u003cbr\u003e\nALKBH; \u003cbr\u003e\nALKBH1; \u003cbr\u003e\nAlkylated DNA repair protein alkB homolog 1; \u003cbr\u003e\nAlkylation repair homolog 1; \u003cbr\u003e\nAlkylation repair, alkB homolog; \u003cbr\u003e\nAlpha-ketoglutarate-dependent dioxygenase ABH1; \u003cbr\u003e\nDNA lyase ABH1; \u003cbr\u003e\nDNA oxidative demethylase ALKBH1; \u003cbr\u003e\nhABH;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant full length Human ALKBH1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923512496307,"sku":"BS7984-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923512529075,"sku":"BS7984-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_53c163b3-9d4c-45ee-9767-d52f73c9f4a9.jpg?v=1703850832","url":"https:\/\/afsbio.com\/products\/alkbh1-polyclonal-antibody-bs7984","provider":"AFSBio Inc.","version":"1.0","type":"link"}