{"product_id":"alkbh3-polyclonal-antibody-bs7871","title":"ALKBH3 Polyclonal Antibody-BS7871","description":"\u003cp\u003eALKBH3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7871-50, BS7871-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q96Q83\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: ALKBH3 (alkB, alkylation repair homolog 3), also known as ABH3, PCA1 (prostate cancer antigen 1), DEPC1 or DEPC-1, is a 286 amino acid member of the AlkB family of proteins and functions as a dioxygenase with a preference for RNA and single stranded DNA substrates. ALKBH3 is one of many homologs of the Escherichia coli protein, AlkB. ALKBH3 is expressed in a wide variety of tissues and localizes to the cytoplasm and the nucleus. It associates with iron and 2-oxoglutarate, coupling the oxidation of substrates to the conversion of 2-oxoglutarate into succinate and CO2. Via oxidative demethylation, ALKBH3 repairs 1-methyladenine and 3-methylcytosine lesions in alkylated DNA and RNA. Its activity is stimulated by ascorbate. Two isoforms exist for ALKBH3 due to alternative splicing of the gene.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ALKBH3 polyclonal antibody detects endogenous levels of ALKBH3 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 33 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot (WB) analysis of ALKBH3 polyclonal antibody\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: ABH3; \u003cbr\u003e\nAlkB homolog 3; \u003cbr\u003e\nalkB, alkylation repair homolog 3 (E. coli); \u003cbr\u003e\nALKB3_HUMAN; \u003cbr\u003e\nALKBH3; \u003cbr\u003e\nAlkylated DNA repair protein alkB homolog 3; \u003cbr\u003e\nalkylation repair homolog 3; \u003cbr\u003e\nAlpha-ketoglutarate-dependent dioxygenase alkB homolog 3; \u003cbr\u003e\nDEPC 1; \u003cbr\u003e\nDEPC-1; \u003cbr\u003e\nDEPC1; \u003cbr\u003e\nEC 1.14.11.; \u003cbr\u003e\nFLJ43614; \u003cbr\u003e\nmABH3; \u003cbr\u003e\nMGC118790; \u003cbr\u003e\nMGC118792; \u003cbr\u003e\nMGC118793; \u003cbr\u003e\nMGC134125; \u003cbr\u003e\nPCA1; \u003cbr\u003e\nProstate cancer antigen 1; \u003cbr\u003e\nprostate cancer antigen-1; \u003cbr\u003e\nRP23-375N21.4;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant full length Human ALKBH3.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923512168627,"sku":"BS7871-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923512201395,"sku":"BS7871-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e964e88a-2ecd-4d03-81ce-30a13551fb5a.jpg?v=1703850822","url":"https:\/\/afsbio.com\/products\/alkbh3-polyclonal-antibody-bs7871","provider":"AFSBio Inc.","version":"1.0","type":"link"}