{"product_id":"alpha-2-macroglobμlin-a2m-polyclonal-antibody-bs76737","title":"Alpha-2-Macroglobμlin (A2M) Polyclonal Antibody - BS76737","description":"\u003cp\u003eAlpha-2-Macroglobμlin (A2M) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS76737-50, BS76737-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobμlin deficiency. This gene is implicated in Alzheimer\u0026amp;apos, s disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: A2M, A2MD, CPAMD5, FWP007, S863-7\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human Alpha-2-Macroglobμlin (Alpha-2-Macroglobμlin (A2M))(NP_000005.2).\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB, 1:500 - 1:2000 IHC, 1:50 - 1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Unmodification\u003c\/p\u003e \n\n\u003cp\u003eMolecular Weight: Refer to figures\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P01023\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45940256309427,"sku":"BS76737-50","price":349.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45940256342195,"sku":"BS76737-100","price":582.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_d8474db2-20f3-4b2c-92df-0d7099582232.jpg?v=1788363543","url":"https:\/\/afsbio.com\/products\/alpha-2-macroglob%ce%bclin-a2m-polyclonal-antibody-bs76737","provider":"AFSBio Inc.","version":"1.0","type":"link"}