{"product_id":"alpha-2-macroglobulin-a2m-polyclonal-antibody-bs76737","title":"Alpha-2-Macroglobulin (A2M) Polyclonal Antibody-BS76737","description":"Alpha-2-Macroglobulin (A2M) Polyclonal Antibody\n\nSizes: 50µl, 100µl\n\nCatalogue Numbers:  BS76737-50, BS76737-100\n\nProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\n\nSwiss-Prot: P01023\n\nHost: Rabbit\n\nReactivity: Human\n\nApplications: WB, IHC\n\nAll Applications: WB,1:500 - 1:2000   |   IHC,1:50 - 1:200\n\nBackground: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.\n\nPurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\n\nStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\n\nSpecificity: Unmodification \n\nExtra Notes: Immunohistochemistry of paraffin-embedded human placenta using Alpha-2-Macroglobulin ) antibody at dilution of 1:100 .Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.\n\nNote: For research use only, not for use in diagnostic procedure.\n\nAlternative Name: A2M; A2MD; CPAMD5; FWP007; S863-7\n\nImmunogen: Recombinant fusion protein of human Alpha-2-Macroglobulin (Alpha-2-Macroglobulin (A2M))(NP_000005.2).\n\nConjugate: Unconjugated\n\nModification: Unmodified ","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42924593152179,"sku":"BS76737-50","price":334.88,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42924593184947,"sku":"BS76737-100","price":576.38,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_c2e24646-bbcf-4608-bb10-e5a61ef2ada1.jpg?v=1703936387","url":"https:\/\/afsbio.com\/products\/alpha-2-macroglobulin-a2m-polyclonal-antibody-bs76737","provider":"AFSBio Inc.","version":"1.0","type":"link"}