{"product_id":"alpha-2-macroglobulin-a2m-rabbit-pab-a1573","title":"Alpha-2-Macroglobulin (A2M) Rabbit pAb - A1573","description":"\u003cp\u003eAlpha-2-Macroglobulin (A2M) Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A1573-20, A1573-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 163kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 163kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment)\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P01023\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: A2MD; CPAMD5; FWP007; S863-7; Alpha-2-Macroglobulin (A2M)\u003c\/p\u003e \n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology Developmental Biology, Ubiquitin, Cardiovascular, Blood, Serum Proteins.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: A2M\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189646549171,"sku":"A1573-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189646581939,"sku":"A1573-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_eb0cc91f-d943-4517-8f3b-2163b0dceda3.png?v=1766431779","url":"https:\/\/afsbio.com\/products\/alpha-2-macroglobulin-a2m-rabbit-pab-a1573","provider":"AFSBio Inc.","version":"1.0","type":"link"}