{"product_id":"alpl-polyclonal-antibody-e-ab-70384","title":"ALPL Polyclonal Antibody - E-AB-70384","description":"\u003cp\u003eALPL Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-70384-60, E-AB-70384-120, E-AB-70384-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ALPL\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: AKP2; Alkaline phosphatase liver\/bone\/kidney; Alkaline phosphatase liver\/bone\/kidney isozyme; Alkaline phosphatase tissue nonspecific isozyme; Alkaline phosphatase; tissue-nonspecific isozyme; Alkaline phosphomonoesterase; Alpl; AP TNAP; AP-TNAP; APTNAP; BAP; FLJ40094; FLJ93059; Glycerophosphatase; HOPS; Liver\/bone\/kidney type alkaline phosphatase; MGC161443; MGC167935; PHOA; PPBT; Tissue non specific alkaline phosphatase; Tissue nonspecific ALP; TNAP; TNSALP\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P05186,P09242,P08289\u003c\/p\u003e\n\n\u003cp\u003eBackground: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver\/bone\/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 200 μg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein corresponding to Mouse Alkaline Phosphatase\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 57kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 55kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146522230963,"sku":"E-AB-70384-60","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146522263731,"sku":"E-AB-70384-120","price":364.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146522296499,"sku":"E-AB-70384-200","price":574.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_26aec395-d337-4fce-8d75-a68710d74bc3.png?v=1710296845","url":"https:\/\/afsbio.com\/products\/alpl-polyclonal-antibody-e-ab-70384","provider":"AFSBio Inc.","version":"1.0","type":"link"}