{"product_id":"als2-polyclonal-antibody-ra31071","title":"ALS2 Polyclonal Antibody - RA31071","description":"\u003cp\u003eALS2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA31071-50, RA31071-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: ALS2, alsin Rho guanine nucleotide exchange factor (ALS2) Homo sapiens The protein encoded by this gene contains an ATS1\/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 57679\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 182\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q96Q42\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45120419561651,"sku":"RA31071-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45120419594419,"sku":"RA31071-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_29c5a6e0-508e-43cb-8e72-12af4c84e2d4.png?v=1773365156","url":"https:\/\/afsbio.com\/products\/als2-polyclonal-antibody-ra31071","provider":"AFSBio Inc.","version":"1.0","type":"link"}