{"product_id":"amacr-polyclonal-antibody-e-ab-40482","title":"AMACR Polyclonal Antibody - E-AB-40482","description":"\u003cp\u003eAMACR Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-40482-60, E-AB-40482-120, E-AB-40482-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: AMACR\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 2 methylacyl CoA racemase; 2-methylacyl-CoA racemase; Alpha methylacyl CoA racemase; Alpha-methylacyl-CoA racemase; Amacr; AMACR; AMACRD; Macr1; RACE; RM\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology, Metabolism, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: O09174\u003c\/p\u003e\n\n\u003cp\u003eBackground: AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB\/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR. It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Mouse Alpha-methylacyl-CoA racemase protein\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen Affinity Purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-1:3000  IHC 1:100-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 42 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 40 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146032939187,"sku":"E-AB-40482-60","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146032971955,"sku":"E-AB-40482-120","price":322.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146033004723,"sku":"E-AB-40482-200","price":532.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b5dac4d1-c4d2-4ca7-9f9d-4c49481d7e25.png?v=1710290199","url":"https:\/\/afsbio.com\/products\/amacr-polyclonal-antibody-e-ab-40482","provider":"AFSBio Inc.","version":"1.0","type":"link"}