{"product_id":"ambra1-rabbit-pab-es8480","title":"AMBRA1 rabbit pAb - ES8480","description":"\u003cp\u003eAMBRA1 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8480-50, ES8480-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: function:Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation., similarity:Contains 3 WD repeats., subunit:Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: autophagy\/beclin-1 regulator 1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, ELISA 1:10000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide of AMBRA1\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 140kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 55626\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q9C0C7\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Endoplasmic reticulum. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome. Mitochondrion. Cytoplasm, cytosol. Nucleus. Cell junction, focal adhesion. Localizes to the cytoskeleton in absence of autophagy induction (PubMed:20921139). Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (PubMed:20921139). Partially localizes at mitochondria in normal conditions (PubMed:21358617). Localizes also to discrete punctae along the ciliary axoneme (By similarity).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202381996211,"sku":"ES8480-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202382028979,"sku":"ES8480-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_f39402c5-d909-4802-90a5-a591a8a9056a.png?v=1767127935","url":"https:\/\/afsbio.com\/products\/ambra1-rabbit-pab-es8480","provider":"AFSBio Inc.","version":"1.0","type":"link"}