{"product_id":"amphiphysin-ii-polyclonal-antibody-bt-ap00412","title":"Amphiphysin II Polyclonal Antibody - BT-AP00412","description":"\u003cp\u003eAmphiphysin II Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00412-20, BT-AP00412-50, BT-AP00412-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology; Microbiology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BIN1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Amphiphysin II Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 64699\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O00499; Mouse: O08539; Rat: O08839\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: BIN1; AMPHL; Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 274; Mouse: 30948; Rat: 117028\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240107303091,"sku":"BT-AP00412-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240107335859,"sku":"BT-AP00412-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240107368627,"sku":"BT-AP00412-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_77a7e6d3-19e8-4de2-8eb8-5e7268038885.png?v=1769403502","url":"https:\/\/afsbio.com\/products\/amphiphysin-ii-polyclonal-antibody-bt-ap00412","provider":"AFSBio Inc.","version":"1.0","type":"link"}