{"product_id":"ampkβ2-rabbit-pab-es20834","title":"AMPKβ2 rabbit pAb - ES20834","description":"\u003cp\u003eAMPKβ2 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20834-50, ES20834-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: PRKAB2; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Protein of AMPKβ2\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 30kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5565\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: O43741\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: nucleoplasm, cytosol, nucleotide-activated protein kinase complex,\u003c\/p\u003e \n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201968070835,"sku":"ES20834-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201968103603,"sku":"ES20834-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_8213a2eb-1182-43c5-963d-f1a002fc2319.png?v=1767119067","url":"https:\/\/afsbio.com\/products\/ampk%ce%b22-rabbit-pab-es20834","provider":"AFSBio Inc.","version":"1.0","type":"link"}