{"product_id":"amyloid-β-polyclonal-antibody-ra21872","title":"Amyloid-β Polyclonal Antibody - RA21872","description":"\u003cp\u003eAmyloid-β Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA21872-50, RA21872-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: amyloid beta precursor protein (APP) Homo sapiens This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1\/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: amyloid beta (A4) precursor protein\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF\/ICC; WB; IHC-p; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 351\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 87\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P05067\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121086423219,"sku":"RA21872-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121086455987,"sku":"RA21872-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b100977c-0c93-481c-9cf3-deee541687ce.png?v=1773370782","url":"https:\/\/afsbio.com\/products\/amyloid-%ce%b2-polyclonal-antibody-ra21872","provider":"AFSBio Inc.","version":"1.0","type":"link"}