{"product_id":"andecaliximab-elisa-kit-db945018","title":"Andecaliximab ELISA Kit - DB945018","description":"\u003cp\u003eAndecaliximab ELISA Kit\u003c\/p\u003e\n\n\u003cp\u003eSize: 96T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: DB945018-96\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eStability and Storage: The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.\u003c\/p\u003e\n\n\u003cp\u003eDetection Method: Colorimetric\u003c\/p\u003e\n\n\u003cp\u003eSample Type: Plasma, Serum\u003c\/p\u003e\n\n\u003cp\u003eAssay Type: Quantitative\u003c\/p\u003e\n\n\u003cp\u003eSensitivity: 0.156 μg\/ml\u003c\/p\u003e\n\n\u003cp\u003eRange: 0.31-5 μg\/mL\u003c\/p\u003e\n\n\u003cp\u003eRecovery: 80-120%\u003c\/p\u003e\n\n\u003cp\u003eBackground: Andecaliximab (formerly GS-5745; Gilead Sciences, Inc.), a recombinant chimeric IgG4 monoclonal antibody (mAb), was engineered to remove T-cell epitopes to reduce immunogenicity risk. Andecaliximab selectively binds and inhibits matrix metalloproteinase-9 (MMP9) with minimal cross-reactivity to other matrix metalloproteinases, including the highly homologous matrix metalloproteinase-2 (MMP-2). Andecaliximab is under development for the treatment of cystic fibrosis, gastric cancer, pancreatic cancer, non-small cell lung cancer (NSCLC), rheumatoid arthritis (RA), Crohn's disease (CD), and ulcerative colitis (UC). In a recent phase 1 dose-escalation study in patients with UC, andecaliximab had good tolerability and was associated with a numerically greater percentage of clinical, endoscopic, and histological responses in patients relative to placebo over a 5-week treatment period. A phase 2\/3 trial, evaluating the safety and efficacy of andecaliximab to induce and maintain clinical remission in patients with moderate to severe UC, was initiated. A planned interim futility analysis following an 8-week induction period in the first 150 patients resulted in the termination of the study due to lack of efficacy.\u003c\/p\u003e\n\n\u003cp\u003eShipping: 2-8 ℃\u003c\/p\u003e\n\n\u003cp\u003eFor Research Use Only.\u003c\/p\u003e","brand":"abinScience","offers":[{"title":"Default Title","offer_id":45353676931251,"sku":"DB945018-96","price":1576.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/abinscience.png?v=1773676488","url":"https:\/\/afsbio.com\/products\/andecaliximab-elisa-kit-db945018","provider":"AFSBio Inc.","version":"1.0","type":"link"}