{"product_id":"anti-avelumab-polyclonal-antibody-av974024","title":"Anti-Avelumab Polyclonal Antibody - AV974024","description":"\u003cp\u003eAnti-Avelumab Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: AV974024-50, AV974024-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eHost species: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: The product is specific for Avelumab. This antibody serves as an excellent positive control for Avelumab immunogenicity (ADA) assays.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Avelumab\u003c\/p\u003e\n\n\u003cp\u003eForm: Liquid\u003c\/p\u003e\n\n\u003cp\u003eStorage buffer: 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eApplications: ELISA\u003c\/p\u003e\n\n\u003cp\u003eTarget: Rabbit polyclonal to Bavencio.\u003c\/p\u003e\n\n\u003cp\u003ePurification: Purified by antigen affinity column.\u003c\/p\u003e\n\n\u003cp\u003eStability and Storage: The product can be stored for 2 - 3 weeks at 2 to 8°C or for up to 12 months at -20°C. Avoid repeated freezing and thawing cycles.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Avelumab with trade name Bavencio, is an FDA-approved drug to treat Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by Avelumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as \"immune checkpoint inhibition.\u003c\/p\u003e\n\n\u003cp\u003eAntibodysystem can customize this product per customer's request including product size, buffer components, etc. For research use only.\u003c\/p\u003e","brand":"abinScience","offers":[{"title":"50μg","offer_id":45357882245299,"sku":"AV974024-50","price":492.8,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":45357882278067,"sku":"AV974024-100","price":949.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/abinscience.png?v=1773676488","url":"https:\/\/afsbio.com\/products\/anti-avelumab-polyclonal-antibody-av974024","provider":"AFSBio Inc.","version":"1.0","type":"link"}