{"product_id":"anti-flu-a-h3n2-ha-hemagglutinin-broadly-neutralizing-reference-antibody-cr8020-vk515096","title":"Anti-Flu A (H3N2) HA\/Hemagglutinin Broadly Neutralizing Reference Antibody (CR8020) - VK515096","description":"\u003cp\u003eAnti-Flu A (H3N2) HA\/Hemagglutinin Broadly Neutralizing Reference Antibody (CR8020)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: VK515096-100, VK515096-1000\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eDescription: CR8020 is a broadly neutralizing antibody (bNAb) targeting the stem region of influenza A virus (IAV) hemagglutinin (HA) and is in phase II trials for prophylactic use against group 2 IAVs. Structural and computational analyses show that CR8020 binds HA residues subject to antigenic drift and host selection pressure, with escape mutations observed in some H7N9 strains. Additionally, effective engagement of Fcγ receptors (FcγR) is crucial for antibody efficacy, but membrane steric hindrance may limit HA-CR8020-FcγR complex formation. These findings highlight epitope mutability and immune complex accessibility as key factors in bNAb development.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Influenza A virus (strain A\/Hong Kong\/1\/1968 H3N2)\u003c\/p\u003e\n\n\u003cp\u003eHost: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: ELISA, Bioactivity: FACS, Functional assay\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG1-lambda\u003c\/p\u003e\n\n\u003cp\u003eTarget: Hemagglutinin, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, HA\u003c\/p\u003e\n\n\u003cp\u003ePurification: Protein A\/G purified from cell culture supernatant.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt;95% purity as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eExpression System: Mammalian Cells\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.\u003c\/p\u003e\n\n\u003cp\u003eStorage Buffer: 0.01M PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eForm: Liquid\u003c\/p\u003e\n\n\u003cp\u003eClone ID: CR8020\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q91MA7\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin Level: Please contact the lab for this information.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"abinScience","offers":[{"title":"100μg","offer_id":46155594072243,"sku":"VK515096-100","price":555.0,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":46155594105011,"sku":"VK515096-1000","price":2226.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Abinscience_logo_for_products.jpg?v=1790954517","url":"https:\/\/afsbio.com\/products\/anti-flu-a-h3n2-ha-hemagglutinin-broadly-neutralizing-reference-antibody-cr8020-vk515096","provider":"AFSBio Inc.","version":"1.0","type":"link"}