{"product_id":"anti-human-cd19-reference-antibody-coltuximab-ruo-hb996016","title":"Anti-Human CD19 Reference Antibody (Coltuximab, RUO) - HB996016","description":"\u003cp\u003eAnti-Human CD19 Reference Antibody (Coltuximab, RUO)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: HB996016-100, HB996016-1000\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eDescription: Coltuximab ravtansine (SAR3419) is an antibody-drug conjugate (ADC) targeting CD19 created by conjugating a derivative of the potent microtubule-acting cytotoxic agent, maytansine, to a version of the anti-CD19 antibody, anti-B4, that was humanized as an IgG1 by variable domain resurfacing. Four different linker-maytansinoid constructs were synthesized (average ∼3.5 maytansinoids\/antibody for each) to evaluate the impact of linker-payload design on the activity of the maytansinoid-ADCs targeting CD19. Anti-CD19 humanized monoclonal antibody conjugated to DM4.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Chimeric\u003c\/p\u003e\n\n\u003cp\u003eApplications: ELISA, Bioactivity: FACS, Functional assay\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: SAR3419, 1269764-99-9\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG1-kappa\u003c\/p\u003e\n\n\u003cp\u003eTarget: CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4\u003c\/p\u003e\n\n\u003cp\u003ePurification: Protein A\/G purified from cell culture supernatant.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt;95% as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eExpression System: Mammalian Cells\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.\u003c\/p\u003e\n\n\u003cp\u003eStorage Buffer: 0.01M PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eForm: Liquid\u003c\/p\u003e\n\n\u003cp\u003eAccession: P15391\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin Level: Contact Us for more information.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"abinScience","offers":[{"title":"100μg","offer_id":46155227791539,"sku":"HB996016-100","price":264.0,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":46155227824307,"sku":"HB996016-1000","price":528.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Abinscience_logo_for_products.jpg?v=1790954517","url":"https:\/\/afsbio.com\/products\/anti-human-cd19-reference-antibody-coltuximab-ruo-hb996016","provider":"AFSBio Inc.","version":"1.0","type":"link"}