{"product_id":"anti-human-cd40-tnfrsf5-reference-antibody-sotigalimab-ruo-hb782116","title":"Anti-Human CD40\/TNFRSF5 Reference Antibody (Sotigalimab, RUO) - HB782116","description":"\u003cp\u003eAnti-Human CD40\/TNFRSF5 Reference Antibody (Sotigalimab, RUO)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: HB782116-100, HB782116-1000\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eDescription: The FDA has granted an orphan drug designation to sotigalimab (APX005M) as a potential therapeutic option for patients with soft tissue sarcoma, according to an announcement from Apexigen Inc., the drug developer.A novel, humanized monoclonal antibody, sotigalimab was designed to stimulate an antitumor immune response and to target CD40, which is a key co-stimulatory receptor that serves to activate innate and adaptive immune systems. When sotigalimab binds to CD40 on antigen-presenting cells, it induces a multifaceted immune response that brings several components of the immune system together to attack the cancer.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Humanized\u003c\/p\u003e\n\n\u003cp\u003eApplications: ELISA, Bioactivity: FACS, Functional assay\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: APX005M, APX-005, APX-005-M, APX-005M, 2305607-45-6\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG1-Kappa\u003c\/p\u003e\n\n\u003cp\u003eTarget: Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, TNFRSF5, CDw40, CD40\u003c\/p\u003e\n\n\u003cp\u003ePurification: Protein A\/G purified from cell culture supernatant.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt;95% purity as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eExpression System: Mammalian Cells\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.\u003c\/p\u003e\n\n\u003cp\u003eStorage Buffer: 0.01M PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eForm: Liquid\u003c\/p\u003e\n\n\u003cp\u003eAccession: P25942\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin Level: Please contact the lab for this information.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"abinScience","offers":[{"title":"100μg","offer_id":46155213013171,"sku":"HB782116-100","price":264.0,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":46155213045939,"sku":"HB782116-1000","price":528.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Abinscience_logo_for_products.jpg?v=1790954517","url":"https:\/\/afsbio.com\/products\/anti-human-cd40-tnfrsf5-reference-antibody-sotigalimab-ruo-hb782116","provider":"AFSBio Inc.","version":"1.0","type":"link"}