{"product_id":"anti-human-fgfr2-reference-antibody-bemarituzumab-ruo-hb863016","title":"Anti-Human FGFR2 Reference Antibody (Bemarituzumab, RUO) - HB863016","description":"\u003cp\u003eAnti-Human FGFR2 Reference Antibody (Bemarituzumab, RUO)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: HB863016-100, HB863016-1000\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eDescription: Bemarituzumab (bema), a first-in-class humanized IgG1 monoclonal antibody, selectively binds to the 2b isoform of the fibroblast growth factor receptor (FGFR2b). Bemarituzumab (FPA144) is a first-in-class humanized immunoglobulin G1 monoclonal antibody specific to the splice-variant FGFR2b that inhibits binding of the ligands FGF7, FGF10, and FGF22. Specifically, bemarituzumab does not inhibit binding of FGF23, the ligand responsible for phosphate and vitamin D metabolism, thereby potentially avoiding the risk of hyperphosphatemia associated with pan-FGFR tyrosine kinase inhibitors. Bemarituzumab is also glycoengineered for increased affinity for the human Fc gamma RIII receptor expressed on natural killer cells, enabling enhanced antibody-dependent cell-mediated cytotoxicity.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Humanized\u003c\/p\u003e\n\n\u003cp\u003eApplications: ELISA, Bioactivity: FACS, Functional assay\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: FPA144, FPA-144, FPA114-A, 1952272-74-0\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG1-kappa\u003c\/p\u003e\n\n\u003cp\u003eTarget: K-sam, KSAM, CD332, Keratinocyte growth factor receptor, Fibroblast growth factor receptor 2, FGFR-2, FGFR2, KGFR, BEK\u003c\/p\u003e\n\n\u003cp\u003ePurification: Protein A\/G purified from cell culture supernatant.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt;95% purity as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eExpression System: Mammalian Cells\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.\u003c\/p\u003e\n\n\u003cp\u003eStorage Buffer: 0.01M PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eForm: Liquid\u003c\/p\u003e\n\n\u003cp\u003eAccession: P21802\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin Level: Please contact the lab for this information.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"abinScience","offers":[{"title":"100μg","offer_id":46155220385971,"sku":"HB863016-100","price":264.0,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":46155220418739,"sku":"HB863016-1000","price":528.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Abinscience_logo_for_products.jpg?v=1790954517","url":"https:\/\/afsbio.com\/products\/anti-human-fgfr2-reference-antibody-bemarituzumab-ruo-hb863016","provider":"AFSBio Inc.","version":"1.0","type":"link"}