{"product_id":"anti-telog4-antibody-against-the-telomeric-g-quadruplex","title":"Anti-TeloG4 - Antibody Against the Telomeric G-quadruplex -","description":"\u003cp\u003eAnti-TeloG4 is an antibody that selectively recognizes the antiparallel topology of the telomeric G-quadruplex sequence. \u003c\/p\u003e\n\u003cdiv class=\"o_colored_level pt0 col-lg-10 pb0\"\u003e\u003cstrong\u003eSizes:\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"o_colored_level pt0 col-lg-10 pb0\"\u003e10µL (IDY-ATG4-10)\u003c\/div\u003e\n\u003cp class=\"o_colored_level pt0 col-lg-10 pb0\"\u003e50µL (IDY-ATG4-50)\u003c\/p\u003e\n\u003cdiv class=\"o_colored_level pt0 col-lg-10 pb0\"\u003e\u003cstrong\u003eCatalogue Numbers:\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"o_colored_level pt0 col-lg-10 pb0\"\u003eIDY-ATG4-10 (10µL)\u003c\/div\u003e\n\u003cp class=\"o_colored_level pt0 col-lg-10 pb0\"\u003eIDY-ATG4-50 (50µL)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKey Features:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSpecific to telomeric G-quaduplex\u003c\/li\u003e\n\u003cli\u003eHigh affinity with a Kd around 10nM\u003c\/li\u003e\n\u003cli\u003eCompatible with immunocytochemistry\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications of Anti-TeloG4 \u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eHost\/isotype: \u003c\/strong\u003eHuman \/IgG1\/K\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClass:\u003c\/strong\u003e monoclonal (recombinant)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eConjugate:\u003c\/strong\u003e unconjugated\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eConcentration: \u003c\/strong\u003e1mg\/mL\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage buffer:\u003c\/strong\u003e PBS, pH=7,4\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecificity:\u003c\/strong\u003e Anti-TeloG4 has a high affinity for telomeric antiparallel G-quadruplex, with no detectable binding to other types of G-quadruplexes (parallel, or non telomeric), RNA G-quadruplexes,  double-stranded DNA or single-stranded RNA, and low affinity to single-stranded DNA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAffinity:\u003c\/strong\u003e The dissociation constant (Kd) for antiparallel G-quadruplex telomeric region is around 10nM.\u003c\/p\u003e\n\u003ch3\u003eApplications of Anti-TeloG4\u003c\/h3\u003e\n\u003cp\u003eImmunocytochemistry (ICC) - Use Anti-TeloG4 at 2µg\/mL (1\/500 dilution)\u003c\/p\u003e\n\u003cp\u003eEnzyme-linked immunosorbent assay (ELISA) - Use Anti-TeloG4 at 0.25 - 1.25µg\/mL (1\/800 -  1\/4000 dilution) depending on the target\u003c\/p\u003e\n\u003ch3\u003eResults\u003c\/h3\u003e\n\u003csection data-name=\"Texte\" data-snippet=\"s_text_block\" class=\"s_text_block pt40 pb0\"\u003e\n\u003cdiv class=\"s_allow_columns container\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"text-o-color-1\"\u003e\u003cspan\u003eHigh selectivity of Anti-TeloG4 to antiparallel telomeric G-quadruplexes\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cimg loading=\"lazy\" data-resize-width=\"690\" data-mimetype-before-conversion=\"image\/png\" data-original-src=\"\/web\/image\/45751-aa6ada28\/anti-teloG4_graph_sp%C3%A9cificit%C3%A9_3.png\" data-original-id=\"45751\" data-mimetype=\"image\/webp\" class=\"img img-fluid o_we_custom_image mx-auto d-block\" alt=\"telomeric, G-quadruplex, G4, specificity, affinity\" src=\"https:\/\/www.idylle-labs.com\/web\/image\/45752-4cb79c62\/anti-teloG4_graph_sp%C3%A9cificit%C3%A9_3.webp?access_token=58cf530c-d42e-422e-ba13-e93b56359f4f\"\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003csection data-name=\"Texte\" data-snippet=\"s_text_block\" class=\"s_text_block pt40 pb40\"\u003e\n\u003cdiv class=\"container s_allow_columns\"\u003e\n\u003cp\u003eNormalized response obtained from BioLayer Interferometry (BLI) for the binding of Anti-TeloG4 with different sequences, revealing a higher affinity to antiparallel telomeric sequences (Tel23, 2, Wt26), compared to non-telomeric or parallel G-quadruplexes sequences. (Legend: Topology of G4 : Antiparallel (A), Hybrid (H), Mixture of parallel and antiparallel (M), Parallel (P);  Telomeric sequence: Yes (+), No (-). \u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eData was adapted from Reda et al, 2025\u003c\/em\u003e\u003c\/p\u003e\n\u003chr class=\"w-75 mx-auto\"\u003e\n\u003cspan class=\"h4-fs\"\u003e\u003cstrong\u003e\u003cspan class=\"text-o-color-1\"\u003eVisualization of telomeric G4 structures by immunocytochemistry with Anti-TeloG4\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003csection data-name=\"Texte\" data-snippet=\"s_text_block\" class=\"s_text_block pt40 pb40\"\u003e\n\u003cdiv class=\"s_allow_columns container\"\u003e\n\u003cp\u003e\u003cimg loading=\"lazy\" data-resize-width=\"1256\" data-mimetype-before-conversion=\"image\/png\" data-original-src=\"\/web\/image\/45736-0fac1019\/anti-teloG4_icc2.png\" data-original-id=\"45736\" data-mimetype=\"image\/webp\" class=\"img img-fluid o_we_custom_image mx-auto d-block\" alt=\"immunocytochemistry, telomere, G-quadruplex, co-localisation\" src=\"https:\/\/www.idylle-labs.com\/web\/image\/45739-c0304294\/anti-teloG4_icc2.webp?access_token=300369f3-54b1-4853-abef-8ebe9dd89754\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCo-localization of TRF2 telomeric protein (red) and Anti-TeloG4 (green) signals in human cancer cells (U2OS)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eData was adapted from Reda et al, 2025 \u003c\/em\u003e\u003c\/p\u003e\n\u003csection class=\"s_text_block pt0 pb4\" data-snippet=\"s_text_block\" data-name=\"Text\"\u003e\n\u003cdiv class=\"s_allow_columns container\"\u003e\n\u003cdiv class=\"s_hr text-start pb32 pt24\" data-snippet=\"s_hr\" data-name=\"Custom Separator\"\u003e\u003chr class=\"w-75 mx-auto\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003csection data-name=\"Texte\" data-snippet=\"s_text_block\" class=\"s_text_block pt40 pb40\"\u003e\n\u003cdiv class=\"s_allow_columns container\"\u003e\n\u003cp\u003e\u003cspan class=\"h4-fs\"\u003e\u003cstrong\u003e\u003cspan class=\"text-o-color-1\"\u003eSignificant variation of signal from Anti-TeloG4 upon treatment with G4 ligands\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cimg loading=\"lazy\" alt=\"G4 ligand, quantification, G-quadruplexes, telomeres\" data-resize-width=\"669\" data-mimetype-before-conversion=\"image\/png\" data-original-src=\"\/web\/image\/45750-d6b129f2\/anti-telog4__graph_icc_2.png\" data-original-id=\"45750\" data-mimetype=\"image\/webp\" class=\"img img-fluid o_we_custom_image mx-auto d-block\" src=\"https:\/\/www.idylle-labs.com\/web\/image\/45753-e4baf76b\/anti-telog4__graph_icc_2.webp?access_token=e9cdecd6-ccef-4406-a2ae-3c7e0fc4e6ae\"\u003e\n\u003cp\u003eQuantification of TRF2 foci (telomeric protein) co-localizing with Anti-TeloG4 in untreated condition and treated with PhenDC3, a G4 ligand known to preferentially bind telomeric G4 structures, or with CX-5461, a G4 ligand primarily targeting ribosomal DNA sequences. This result strongly suggests that Anti-TeloG4 preferentially binds to antiparallel G4 structures stabilized at telomeres.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eData was obtained from Reda et al, 2025\u003c\/em\u003e\u003cem\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Idylle","offers":[{"title":"10µL","offer_id":45284880056499,"sku":null,"price":442.4,"currency_code":"CAD","in_stock":true},{"title":"50µL","offer_id":45284880089267,"sku":null,"price":1060.68,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/5BIDY-ATG4-10_5D_20Anti-TeloG4_20-_20Antibody_20against_20the_20telomeric_20G-quadruplex_20_2810_C2_B5L_29.png?v=1771440548","url":"https:\/\/afsbio.com\/products\/anti-telog4-antibody-against-the-telomeric-g-quadruplex","provider":"AFSBio Inc.","version":"1.0","type":"link"}