{"product_id":"antr1-polyclonal-antibody-bt-ap06293","title":"ANTR1 Polyclonal Antibody - BT-AP06293","description":"\u003cp\u003eANTR1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06293-20, BT-AP06293-50, BT-AP06293-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cardiovascular; Microbiology; Tags and cell markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ANTXR1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Anthrax toxin receptor 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9H6X2; Mouse: Q9CZ52; Rat: Q0PMD2\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Anthrax toxin receptor 1;Tumor endothelial marker 8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 84168\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239052009651,"sku":"BT-AP06293-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239052042419,"sku":"BT-AP06293-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239052075187,"sku":"BT-AP06293-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_644cd771-ab77-42b4-bf81-3bcd227cf92c.png?v=1769388441","url":"https:\/\/afsbio.com\/products\/antr1-polyclonal-antibody-bt-ap06293","provider":"AFSBio Inc.","version":"1.0","type":"link"}