{"product_id":"ap4e1-rabbit-polyclonal-antibody-es18303","title":"AP4E1 Rabbit Polyclonal Antibody - ES18303","description":"\u003cp\u003eAP4E1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES18303-50, ES18303-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human AP4E1 AA range: 104-154\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: AP4E1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of AP4E1 at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 125kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Lysosome\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system\u003cbr\u003e\nSimilarity: Belongs to the adaptor complexes large subunit family\u003cbr\u003e\nSubcellular Location: Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells\u003cbr\u003e\nSubunit: Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1)\u003cbr\u003e\nTissue Specificity: Widely expressed\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: AP4E1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: AP4E1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 108011\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q80V94\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315795579059,"sku":"ES18303-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315795611827,"sku":"ES18303-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/ap4e1-rabbit-polyclonal-antibody-es18303","provider":"AFSBio Inc.","version":"1.0","type":"link"}