{"product_id":"apc-anti-human-cd197-ccr7-antibody-g043h7-e-ab-f1159e","title":"APC Anti-Human CD197\/CCR7 Antibody [G043H7] - E-AB-F1159E","description":"\u003cp\u003eAPC Anti-Human CD197\/CCR7 Antibody [G043H7]\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100 Tests, 100 Tests×2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-F1159E-100, E-AB-F1159E-100×2\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD197\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CMKBR7, EBI1, EVI1, CCR-7, CDw197,\u003c\/p\u003e \n\n\u003cp\u003eConjugation: APC\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: FCM\u003c\/p\u003e\n\n\u003cp\u003eUsage: Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2a, κ\u003c\/p\u003e\n\n\u003cp\u003eClone No.: G043H7\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P32248\u003c\/p\u003e\n\n\u003cp\u003eBackground: CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. naive T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells, this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 5 μL\/Test\u003c\/p\u003e\n\n\u003cp\u003eControl Catalogue Number: E-AB-F09802E\u003c\/p\u003e\n\n\u003cp\u003eBuffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.\u003c\/p\u003e\n\n\u003cp\u003eGene ID: 1236\u003c\/p\u003e\n\n\u003cp\u003eStorage: This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100 Tests","offer_id":43157157380275,"sku":"E-AB-F1159E-100","price":403.2,"currency_code":"CAD","in_stock":true},{"title":"100 Tests×2","offer_id":43157157413043,"sku":"E-AB-F1159E-100×2","price":604.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_fec3246b-def6-49a8-8354-8c28cf85932f.png?v=1710511703","url":"https:\/\/afsbio.com\/products\/apc-anti-human-cd197-ccr7-antibody-g043h7-e-ab-f1159e","provider":"AFSBio Inc.","version":"1.0","type":"link"}