{"product_id":"apc-anti-mouse-cd22-antibody-cy34-1-e-ab-f1021e","title":"APC Anti-Mouse CD22 Antibody [Cy34.1] - E-AB-F1021E","description":"\u003cp\u003eAPC Anti-Mouse CD22 Antibody [Cy34.1]\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100 Tests, 100 Tests×2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-F1021E-100, E-AB-F1021E-100×2\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD22\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: B-cell receptor CD22, Cd22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14, CD22, Lyb-8, Siglec2,\u003c\/p\u003e \n\n\u003cp\u003eConjugation: APC\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: FCM\u003c\/p\u003e\n\n\u003cp\u003eUsage: Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1, κ\u003c\/p\u003e\n\n\u003cp\u003eClone No.: Cy34.1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P35329\u003c\/p\u003e\n\n\u003cp\u003eBackground: The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB\/c, CBA, C3H\/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA\/1, DBA\/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig μ chain are augmented in the presence of Cy34.1 mAb.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 5 μL\/Test\u003c\/p\u003e\n\n\u003cp\u003eControl Catalogue Number: E-AB-F09792E\u003c\/p\u003e\n\n\u003cp\u003eBuffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.\u003c\/p\u003e\n\n\u003cp\u003eGene ID: 12483\u003c\/p\u003e\n\n\u003cp\u003eStorage: This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100 Tests","offer_id":43157079949491,"sku":"E-AB-F1021E-100","price":140.0,"currency_code":"CAD","in_stock":true},{"title":"100 Tests×2","offer_id":43157079982259,"sku":"E-AB-F1021E-100×2","price":224.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b0066292-c7a3-48b6-a4ed-099aabbb48a7.png?v=1710510504","url":"https:\/\/afsbio.com\/products\/apc-anti-mouse-cd22-antibody-cy34-1-e-ab-f1021e","provider":"AFSBio Inc.","version":"1.0","type":"link"}