{"product_id":"apc-anti-mouse-cd279-pd-1-antibody-29f-1a12-e-ab-f1131ue","title":"APC Anti-Mouse CD279\/PD-1 Antibody [29F.1A12] - E-AB-F1131UE","description":"\u003cp\u003eAPC Anti-Mouse CD279\/PD-1 Antibody [29F.1A12]\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: E-AB-F1131UE-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD279\/PD-1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PD-1, Programmed Death-1,\u003c\/p\u003e \n\n\u003cp\u003eConjugation: APC\u003c\/p\u003e\n\n\u003cp\u003eHost: Rat\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: FCM\u003c\/p\u003e\n\n\u003cp\u003eUsage: Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg\/10^6 cells in 100 μL volume].\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Rat IgG2a, κ\u003c\/p\u003e\n\n\u003cp\u003eClone No.: 29F.1A12\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q02242\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.2 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eControl Catalogue Number: E-AB-F09833E\u003c\/p\u003e\n\n\u003cp\u003eBuffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 18566\u003c\/p\u003e\n\n\u003cp\u003eStorage: This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43157400125619,"sku":"E-AB-F1131UE-100","price":319.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b7a9500b-b1e0-404f-853b-77a55f5a4dc2.png?v=1710514278","url":"https:\/\/afsbio.com\/products\/apc-anti-mouse-cd279-pd-1-antibody-29f-1a12-e-ab-f1131ue","provider":"AFSBio Inc.","version":"1.0","type":"link"}