{"product_id":"apc-rabbit-anti-human-cd95-fas-monoclonal-antibody-a27982","title":"APC Rabbit anti-Human CD95\/FAS Monoclonal Antibody - A27982","description":"\u003cp\u003eAPC Rabbit anti-Human CD95\/FAS Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A27982-100, A27982-200, A27982-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3\/ERK1, and MAPK8\/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 38kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 355\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P25445\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Protein phosphorylation, Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, Death Receptor Signaling Pathway, Immunology Inflammation, CDs, Cytokines, Cell Intrinsic Innate Immunity Signaling Pathway, Neuroscience, Neurodegenerative Diseases\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: FAS\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: APC. Ex:650nm. Em:660nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC74903\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189330436275,"sku":"A27982-100","price":403.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189330469043,"sku":"A27982-200","price":711.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189330501811,"sku":"A27982-500","price":1579.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_be2e4cd4-6efa-4bf0-bf32-5cb709de8cc8.png?v=1766421575","url":"https:\/\/afsbio.com\/products\/apc-rabbit-anti-human-cd95-fas-monoclonal-antibody-a27982","provider":"AFSBio Inc.","version":"1.0","type":"link"}