{"product_id":"apc5-polyclonal-antibody-bt-ap00512","title":"APC5 Polyclonal Antibody - BT-AP00512","description":"\u003cp\u003eAPC5 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00512-20, BT-AP00512-50, BT-AP00512-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: ANAPC5 encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex\/cyclosome (APC\/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein (anaphase promoting complex subunit 5) is required for the proper ubiquitination function of APC\/C and for the interaction of APC\/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ANAPC5\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: APC5 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 85077\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9UJX4; Mouse: Q8BTZ4\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ANAPC5; APC5; Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 51433\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240112971955,"sku":"BT-AP00512-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240113004723,"sku":"BT-AP00512-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240113037491,"sku":"BT-AP00512-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_968a114b-6c51-439f-8932-f8980f2a7f5c.png?v=1769403594","url":"https:\/\/afsbio.com\/products\/apc5-polyclonal-antibody-bt-ap00512","provider":"AFSBio Inc.","version":"1.0","type":"link"}