{"product_id":"apobec4-polyclonal-antibody-bs62444","title":"APOBEC4 Polyclonal Antibody-BS62444","description":"\u003cp\u003eAPOBEC4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS62444-50, BS62444-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q8WW27\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB:1:500~1:1000\u003c\/p\u003e \n\n\u003cp\u003eBackground: The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein (Cas9) system is an adaptive immune response defense mechanism used by archea and bacteria for the degradation of foreign genetic material. This mechanism can be repurposed for other functions, including genomic engineering for mammalian systems, such as gene knockout (KO) and gene activation. CRISPR Activation Plasmid products enable the identification and upregulation of specific genes by utilizing a D10A and N863A deactivated Cas9 (dCas9) nuclease fused to a VP64 activation domain, in conjunction with sgRNA (MS2), a target-specific sgRNA engineered to bind the MS2-P65-HSF1 fusion protein. This synergistic activation mediator (SAM) transcription activation system provides a robust system to maximize the activation of endogenous gene expression.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The protein was purified from E.coli and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: APOBEC4 polyclonal antibody detects endogenous levels of APOBEC4 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of APOBEC4 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLaneA:The testis tissue lysate of Rat\u003cbr\u003e\nLaneB:The testis tissue lysate of Mouse\u003cbr\u003e\nLaneC:MCF-7 whole cell lysate\u003cbr\u003e\nLaneD:PC3 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 42 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Putative C-\u0026gt;U-editing enzyme APOBEC-4; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4; APOBEC4; C1orf169\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human APOBEC4.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910458675379,"sku":"BS62444-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910458708147,"sku":"BS62444-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_064f108b-d040-403a-9334-e6a7fd2f709f.jpg?v=1703092814","url":"https:\/\/afsbio.com\/products\/apobec4-polyclonal-antibody-bs62444","provider":"AFSBio Inc.","version":"1.0","type":"link"}