{"product_id":"apoe-monoclonal-antibody-bt-mca2960","title":"ApoE Monoclonal Antibody - BT-MCA2960","description":"\u003cp\u003eApoE Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2960-50, BT-MCA2960-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Tissue specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience, Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ApoE\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 1H4\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: ApoE\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human ApoE expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 36kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P02649\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: AD2, LPG, LDLCQ5, MGC1571\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 348\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238597648563,"sku":"BT-MCA2960-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238597681331,"sku":"BT-MCA2960-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_62f3ba6e-d1e5-4429-9c43-bb269c634766.png?v=1769382924","url":"https:\/\/afsbio.com\/products\/apoe-monoclonal-antibody-bt-mca2960","provider":"AFSBio Inc.","version":"1.0","type":"link"}