{"product_id":"app-monoclonal-antibody-bt-mca2109","title":"APP Monoclonal Antibody - BT-MCA2109","description":"\u003cp\u003eAPP Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2109-50, BT-MCA2109-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1\/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: APP\u003c\/p\u003e\n\n\u003cp\u003eApplications: ICC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 3F12F6\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: APP\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human APP (AA: 483-699) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 87kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P05067\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 351\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238563406003,"sku":"BT-MCA2109-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238563438771,"sku":"BT-MCA2109-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_e018957d-3385-4e23-9f8b-130f1852534b.png?v=1769382611","url":"https:\/\/afsbio.com\/products\/app-monoclonal-antibody-bt-mca2109","provider":"AFSBio Inc.","version":"1.0","type":"link"}