{"product_id":"app-monoclonal-antibody-bt-mca3013","title":"APP Monoclonal Antibody - BT-MCA3013","description":"\u003cp\u003eAPP Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3013-50, BT-MCA3013-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Amyloid precursor protein(APP) ,with 32-amino acid protein (about 35 kDa), is part of a super-family of transmembrane and secreted proteins. It appears to have a number of roles, including regulation of haemostasis and mediation of neuroprotection. APP undergoes alternative splicing, resulting in several isoforms . Proteolytic cleavage of amyloid precursor protein leads to the formation of the 4 kDa amyloid beta\/A4 protein, which is present in human platelets. APP is also involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer patients.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: APP\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 1B11F3\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2a\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: APP\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of APP expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P05067\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: APP\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 351\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238376497331,"sku":"BT-MCA3013-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238376530099,"sku":"BT-MCA3013-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_594e4d90-25e8-4dd8-989e-3ba991e7a142.png?v=1769379467","url":"https:\/\/afsbio.com\/products\/app-monoclonal-antibody-bt-mca3013","provider":"AFSBio Inc.","version":"1.0","type":"link"}