{"product_id":"ar-β2-rabbit-polyclonal-antibody-es1713","title":"AR-β2 Rabbit Polyclonal Antibody - ES1713","description":"\u003cp\u003eAR-β2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1713-50, ES1713-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and\/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, FCM, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ADRB2, ADRB2R, B2AR, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor beta2. AA range:321-370\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Adrenergic Receptor β2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: AR-β2 Polyclonal Antibody detects endogenous levels of AR-β2 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. Flow cytometry: 1\/200 - 1\/400. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Blood, Brain, Fetal brain, Heart, Leukocyte, Prostate, Thyroid,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 47kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Polymorphic forms of ADRB2 could impart some form of nocturnal asthma\u003cbr\u003e\nFunction: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine\u003cbr\u003e\nPTM: Palmitoylated, may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation\u003cbr\u003e\nPTM: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage, probably by ATM or ATR\u003cbr\u003e\nPTM: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the recep\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein Early endosome Golgi apparatus Colocalizes with VHL at the cell membrane (PubMed:19584355) Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325) Activated receptors are also detected within the Golgi apparatus (PubMed:27481942)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: ADRB2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Beta-2 adrenergic receptor\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P18762\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315530158259,"sku":"ES1713-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315530191027,"sku":"ES1713-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/ar-%ce%b22-rabbit-polyclonal-antibody-es1713","provider":"AFSBio Inc.","version":"1.0","type":"link"}