{"product_id":"areb6-monoclonal-antibody-mb66977","title":"AREB6 Monoclonal Antibody - MB66977","description":"\u003cp\u003eAREB6 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66977-50, MB66977-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: ZEB family proteins are zinc-finger and homeobox domain containing transcription factors. There are two members in mammals, ZEB1 (δ-EF1, TCF8, AREB6) and ZEB2 (SIP1). ZEB1 and ZEB2 contain two separate zinc-finger domains and a homeodomain (1). While ZEB proteins mainly function as transcriptional suppressors, they are able to activate transcription, dependent on DNA-context and cell type . One of the targets suppressed by ZEB proteins is E-cadherin. Downregμlation of E-cadherin is one of the hallmarks of epithelial mesenchymal transition (EMT), a critical feature of normal embryonic development, which is also utilized by malignant epithelial tumors to spread beyond their origin . ZEB1 mutations are associated with posterior corneal dystrophy, and ZEB2 mutations were reported to be associated with Hirschsprung (HSCR) disease .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: AREB6, TCF8, Zinc finger E-box-binding homeobox 1, NIL-2-A zinc finger protein, Negative regμlator of IL2, Transcription factor 8, TCF-8\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AREB6. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/5000), FC (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of AREB6 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 95 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Adherens Junction signaling, Wntβ catenin signaling.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P37275\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1 kappa. Supplied in crude ascites with 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946158153907,"sku":"MB66977-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946158186675,"sku":"MB66977-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/areb6-monoclonal-antibody-mb66977","provider":"AFSBio Inc.","version":"1.0","type":"link"}